Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores
نویسندگان
چکیده
منابع مشابه
MR Lymphangiography Using Nano-Sized Paramagnetic Contrast Agents with Dendrimer Cores
Imaging of the lymphatic system is difficult because its channels and lymph nodes are small and not directly accessible. Currently, two clinical methods, the direct lymphangiography and the lymphoscintigraphy, are used to visualize parts of the human lymphatic system, but have significant limitations. Nano-sized contrast agents have recently been evaluated to be advantageous for visualization o...
متن کاملNovel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
One of the major limitations to macromolecular MRI contrast agents (MRI-CAs) is their slow clearance and associated decreased excretion of gadolinium (Gd(III)). The effect of coinjecting lysine to accelerate renal excretion of a macromolecular MRI-CA (generation-4 PAMAM dendrimer (G4D-(1B4M-Gd)64)) was investigated. The biodistribution and urine and fecal excretion in athymic mice was evaluated...
متن کاملDendrimer-based MRI contrast agents: the effects of PEGylation on relaxivity and pharmacokinetics.
UNLABELLED Polyethylene glycol (PEG) surface modification can make nanomaterials highly hydrophilic, reducing their sequestration in the reticuloendothelial system. In this study, polyamidoamine (PAMAM) dendrimers bearing gadolinium (Gd) chelates were PEGylated with different PEG-chain lengths, and the effects on paramagnetic and pharmacokinetic properties were evaluated. Specifically, Gd chela...
متن کاملMR Contrast Agents
Despite the excellent soft tissue contrast pro› vided by plain MRI, the use of intravascular contrast agents is often performed in a variety of clinical settings being an instrumental component of many MR studies. Several compounds have been developed for contrast-enhanced MR imaging of the abdomen, with the purpose of increasing tumor detection and differentiation between normal and pathologic...
متن کاملProton relaxation enhancement associated with iodinated contrast agents in MR imaging of the CNS.
PURPOSE To study the effects of iodinated radiographic contrast agents on proton relaxation in MR imaging. PATIENTS AND METHODS Two patients were evaluated after the intrathecal administration of an iodinated nonionic contrast agent (Isovue) and five subjects with cranial tumors following the intravenous administration of an iodinated ionic contrast medium (Renografin). RESULTS Both patient...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2001
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.1314